The Role of L-5 MTHF Supplement in Depression
Folate is a vitamin that is essential (amongst other things) for protein metabolism, the formation of red blood cells, cell growth, cell division, as well as prevention of neural tube defects. It is naturally found in beans, fruits, grains, vegetables, and other foods. However, the inability to fully absorb or metabolize folate can result in a deficiency.
Aside from anemia and other health issues, folate deficiency may also lead to the development of MDD or Major Depressive Disorder. Furthermore, having either a problem with malabsorption or folate insufficiency is correlated with lower response to antidepressant medications.
In some cases where a medical problem hinders the absorption of folic acid or when folate deficiency is found — l-methylfolate (l-5 mthf) — is then highly advised.
Role of L-5 MTHF Supplement in Depression
Studies show that depression is the leading cause of disability in the US among people aged 15 to 44. In 2016, around 16.2 million adults aged 18 years or older in the U.S. had experienced at least one major depressive episode. It is also more prevalent in women than in men.
Moreover, approximately 50–70% of people on antidepressant medications fail to have a remission of their depressive episode. For these individuals, case studies and clinical trials highly suggest that l-5 mthf supplement can enhance their response to antidepressants. Although atypical antipsychotic prescriptions are sometimes used to increase the effects of antidepressants, these drugs are commonly associated with the side effects such as dyslipidemia and weight gain.
That is why some researchers have advocated the use of l-5 MTHF supplementation for those people who don’t respond well to antidepressants medications alone. In general, l-5 MTHF is well-tolerated and it has not been shown to induce the side effects that are commonly associated with antipsychotics. Over-the-counter brands are also relatively inexpensive.
How Does L-Methylfolate Work?
L-Methylfolate is a form of folic acid that passes through the blood-brain barrier and acts a major role in the synthesis of neurotransmitters. It indirectly aids the structure of dopamine, serotonin, and norepinephrine, which are responsible for mood regulation and other significant functions.
Several studies have shown how l-methylfolate may establish an efficient, safe, and well-tolerated treatment approach for people with MDD or Major Depressive Disorder who have previously had either no response or a partial response to SSRIs.
Review and Suggestions
Folate malabsorption or deficiency due to illness, medications, or other health issues can increase the risk of developing MDD. An l-5 MTHF supplement may be helpful for those who have MDD that has not responded adequately to antidepressant medications alone.
A careful assessment of symptoms should also be a part of the medical evaluation, as blood levels of folate may not precisely indicate the levels in the central nervous system.
Lastly, those who are on medications or those who have pre-existing medical conditions should first discuss with their physicians about whether l-5 MTHF supplementation is recommended. The dosage should be based on your medical condition, as well as your response to treatment. If your physician prescribed the use of the supplement, remember to take them regularly to get the most benefit from it
Resources:
Papakostas GI, Shelton RC, Zajecka JM, Etemad B, Rickels K, & Clain A, et al. (2012). L-methylfolate as adjunctive therapy for SSRI-resistant major depression: results of two randomized, double-blind, parallel-sequential trials. American Journal of Psychiatry. (link is external) 169(12), 1267–74.
WebMD: L-Methylfolate:
https://www.webmd.com/drugs/2/drug-162998/l-methylfolate-oral/details
Anxiety and Depression Association of America: Facts and Statistics. https://adaa.org/about-adaa/press-room/facts-statistics
Johns Hopkins: Anemia of Folate Deficiency.
National Institute of Mental Health: Major Depression.
https://www.nimh.nih.gov/health/statistics/major-depression.shtml
